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White Powder Local Anesthetic Powder Lidocaine CAS 137-58-6 For Pain Killer Lidocaine Base

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White Powder Local Anesthetic Powder Lidocaine CAS 137-58-6 For Pain Killer Lidocaine Base

Brand Name : Lidocaine
Model Number : Lidocaine
Certification : GMP/ISO9001, USP,BP
Place of Origin : China
MOQ : 100G
Price : Negotiation
Payment Terms : L/C, T/T, Western Union, MoneyGram
Supply Ability : 10000kg/month
Delivery Time : Within 3-7 work days after payment confirmed.
Packaging Details : Customized.
Product Name : Lidocaine
CAS : 137-58-6
MF : C14H22N2O
MW : 234.34
EINECS : 205-302-8
Melting point : 66-69°C
Fp : 9℃
storage temp. : Store at RT
solubility : ethanol: 4 mg/mL
form : powder
color : White to slightly yellow
Water Solubility : practically insoluble
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White Powder Local Anesthetic Powder Lidocaine CAS 137-58-6 For Pain Killer Lidocaine Base


Lidocaine base information

Product Name: Lidocaine
CAS: 137-58-6
Assay: 99%
MF: C14H22N2O
MW: 234.34
EINECS: 205-302-8
Appearance: White powder
Usage: Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Usage: antihypertensive
Usage: Anticonvulsant

Description


Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by Eutectic Mixture of Local Anesthetics.

The lidocaine/prilocaine combination is indicated for dermal anaesthesia. Specifically it is applied to prevent pain associated with intravenous catheter insertion, blood sampling, superficial surgical procedures; and topical anaesthesia of leg ulcers for cleansing or debridement. Also, it can be used to
numb the skin before tattooing as well as electrolysis and laser hair removal.

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.

Applications

Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

Lidocaine Specification


TEST ITEMSSPECIFICATIONRESULTS
CharactersA white or almost white crystalline powderA white crystalline powder
IdentificationInfrared absorption spectrum of the substance is same as that of Lidocaine Intermediate CRSConforms
Clarity and color of the solutionClear and colorless≤Y6Conforms
PHDissolve 2.0g in water and dilute to 20ml ph 3.5~5.54.3
Optical rotation4%(W/V)Water solution +135°~+150°+140°
Heavy metal≤5ppm<5ppm
Sulphated ash≤0.5%0.02%
Water content3.1~4.6%4.1%
Acetone≤0.5%0.04%
Butyl alcohol≤0.5%0.004%
Bacterial endotoxins≤0.5 CFU/g<0.5 CFU/g0.5 CFU/g
Assay89.5%~102.0%95.9%
B of Lidocaine≤5.0%5.0
ConclusionThe specification conform with enterprise standard


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White Powder Local Anesthetic Powder Lidocaine CAS 137-58-6 For Pain Killer Lidocaine Base Images

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