Local Anaesthesia Procaine hydrochloride CAS: 51-05-8 Top Purity
Procaine hydrochloride, also called Novocain, or Novocaine,
synthetic organic compound used in medicine as a local anesthetic.
Introduced in 1905 under the trade name Novocaine, it became the
first and best-known substitute for cocaine in local anesthesia.
Generally used in a 1 to 10 percent saline solution, procaine
hydrochloride is administered by injection for infiltration (area
flooding as in dental anesthesia), nerve-block, spinal, and caudal
anesthesia. Unlike cocaine, procaine is not toxic, addicting, or
irritating. It has been displaced somewhat by the chemically
related drugs lidocaine and mepivacaine, which produce prompter,
more intense anesthesia.
Name: Procaine hydrochloride (JP17/USP); Novocain (TN)
Formal Name: 4-amino-benzoic acid, 2-(diethylamino)ethyl ester,
Formula: C13H20N2O2. HCl
Exact mass: 272.1292
Mol weight: 272.771
Formulation: A crystalline solid
λmax: 225, 299, 484 nm
Stability: ≥ 2 years
|Product name||Procaine hydrochloride|
|CAS No.||51-05-8||Outer Packing||25kg/drum|
|Production date||2017.03.28||Shelf life||2020.03.27|
|Items of analysis||Specification||Results|
|Description Melting point||A white crystalline powder or colourless 153-158℃||Complies 155.1-156.8℃|
|Color and clarity of solution Heavy metals||Colorless and clea ≤0.002%||Conforms ＜0.002%|
|PH(Acidity) Related substances||5.0-6.5(≤0.02NNaOH0.5ml) ≤0.05%(Sum≤1.0%)||5.5/0.2ml Conforms|
|Loss on drying Residue on ignition||≤0.5% ≤0.1%||0.16% 0.04%|
|Assay Bacterical endotoxins||99.0-101.0% ≤0.6EU/mg||99.6% ＜0.6EU/mg|
Usage of Procaine hydrochloride:
The primary use for procaine is as an anaesthetic.
Procaine is used less frequently today since more effective (and
hypoallergenic) alternatives such as lidocaine (Xylocaine) exist.
Like other local anesthetics (such as mepivacaine, and prilocaine),
procaine is a vasodilator, thus is often coadministered with
epinephrine for the purpose of vasoconstriction. Vasoconstriction
helps to reduce bleeding, increases the duration and quality of
anesthesia, prevents the drug from reaching systemic circulation in
large amounts, and overall reduces the amount of anesthetic
required.Unlike cocaine, a vasoconstrictor, procaine does not have
the euphoric and addictive qualities that put it at risk for abuse.
Procaine, an ester anesthetic, is metabolized in the plasma by the
enzyme pseudocholinesterase through hydrolysis into para-amino
benzoic acid (PABA), which is then excreted by the kidneys into the
Procaine is the primary ingredient in the controversial preparation
Gerovital H3 by Ana Aslan (Romania), which is claimed by its
advocates to remedy many effects of aging. The mainstream medical
view is that these claims were seriously studied and discredited in
A 1% procaine injection has been recommended for the treatment of
extravasation complications associated with venipuncture (along
with moist heat, steroids, and antibiotics). It has likewise been
recommended for treatment of inadvertent intra-arterial injections
(10 ml of 1% procaine), as it helps relieve pain and vascular
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