99% purity CAS 73-78-9 local anesthetic pharmaceutical Raw
lidocaine hydrochloride/ HCl
Product name: Lidocaine HCl
Alias: Lidocaine hydrochloride
CAS number: 73-78-9
Appearance: White crystalline powder
Molecular formula: C14H23ClN2O
Molecular weight: 270.8
Melting point: 80-82°C
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TradeMark Standard:USP BP Audited by Made-in -china Supplier
Company certificate:ISO9001 SGS
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Lidocaine, as a local anesthetic, is characterized by a rapid onset
of action and intermediate duration of efficacy. Therefore,
lidocaine is suitable for infiltration, block and surface
anesthesia. Longer-acting substances such as bupivacaine are
sometimes given preference for subdural and epidural anesthesias.
lidocaine, on the other hand, has the advantage of a rapid onset of
action. It can stop Epinephrine (aka adrenaline) vasoconstricts
arteries form bleeding, and it can also delays the resorption of
lidocaine, almost doubling the duration of anaesthesia. For surface
anesthesia several formulations are available that can be used e.g.
for endoscopies, before intubations etc. Buffering the pH of
lidocaine makes local freezing less painful. Lidocaine drops can be
used on the eyes for short ophthalmic procedures.
Topical lidocaine has been shown in some patients to relieve the
pain of postherpetic neuralgia (a complication of shingles), though
there is not enough study evidence to recommend it as a first-line
treatment. IV lidocaine also has uses as a temporary fix for
tinnitus. Although not completely curing the disorder, it has been
shown to reduce the effects by around two thirds.Lidocaine
hydrochloride injection administered intravenously or
intramuscularly, is specifically indicated in the acute management
of ventricular arrhythmias such as those occurring in relation to
acute myocardial infarction, or during cardiac manipulation, such
as cardiac surgery.
Lidocaine may be absorbed following topical administration to
mucous membranes, its rate and extent of absorption depending upon
concentration and total dose administered, the specific site of
application, and duration of exposure. In general, the rate of
absorption of local anesthetic agents following topical application
occurs most rapidly after intratracheal administration. Lidocaine
is also well-absorbed from the gastrointestinal tract, but little
intact drug may appear in the circulation because of
biotransformation in the liver.
Lidocaine is metabolized rapidly by the liver, and metabolites and
unchanged drug are excreted by the kidneys. Biotransformation
includes oxidative N-dealkylation, ring hydroxylation, cleavage of
the amide linkage, and conjugation. N-dealkylation, a major pathway
of biotransformation, yields the metabolites
monoethylglycinexylidide and glycinexylidide.
The plasma binding of lidocaine is dependent on drug concentration,
and the fraction bound decreases with increasing concentration. At
concentrations of 1 to 4 mcg of free base per mL, 60 to 80 percent
of lidocaine is protein bound. Binding is also dependent on the
plasma concentration of the alpha-1-acid glycoprotein.
4.Are you looking for more Local anesthetics?
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