CAS 62-44-2 Painkiller Local Anesthetic Drugs Phenacetin ,
Acetophenetidin White Powder
Phenacetin (or acetophenetidin) is a pain-relieving and
fever-reducing drug, which was widely used between its introduction
in 1887 and the 1983 ban imposed by the FDA on its use in the
United States. Its use has declined because of its adverse effects,
which include increased risk of certain cancers and kidney damage.
It is metabolized as paracetamol (acetaminophen), which replaced it
in some over-the-counter medications following the ban on
Chemical name: Phenacetin
Synonyms: N-(4-Ethoxyphenyl)acetamide; p-Acetophenetidide;
4-Ethoxyacetanilide; 4’-Ethoxyacetanilide; Aceto-4-phenetidine;
Acetophenetidin; Acetophenetidine; Acetophenetin; Acetphenetidin;
Fenidina; Fenina; Kalmin; N-Acetyl-4-ethoxyaniline;
N-Acetyl-p-ethoxyaniline; N-Acetyl-p-phenetidine; NSC 7651;
Pertonal; Phenacetine; Phenazetin; Phenedina; Phenidin; Phenin;
CAS Number: 62-44-2
Molecular form: C10H13NO2
Appearance: White Solid
Melting Point: 134-136°C
Mol. Weight: 179.22
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Pharmaceuticals, Intermediates &
Boiling Point: No Data Available
Applications: Analgesic, antipyretic. Component of APC tablets,
analgesic mixture also containing aspirin and caffeine.
Phenacetin is reasonably anticipated to be a human carcinogen;
analgesic mixtures containing Phenacetin are listed as known human
How It Works
Its analgesic effects are due to its actions on the sensory tracts
of the spinal cord. In addition, phenacetin has a depressant action
on the heart, where it acts as a negative inotrope. It is an
antipyretic, acting on the brain to decrease the temperature set
point. It is also used to treat rheumatoid arthritis (subacute
type) and intercostal neuralgia.
It is metabolised in the body as paracetamol (acetaminophen).
Analgesic mixtures containing phenacetin were previously marketed
as tablets or capsules containing between 150 and 300 mg
phenacetin. Common combinations were: 150 mg phenacetin, 230 mg
aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg
aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate.
Phenacetin alone was also available in 250 and 300 mg doses as
tablets, and up to 500 mg doses as powder. The usual dose was 300
mg 4-6 times per day, and the daily dose was not to exceed 2 g.
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