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Male Sex Hormone Steroids Avanafil CAS 171596-29-5 for Sex Enhancement

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Male Sex Hormone Steroids Avanafil CAS 171596-29-5 for Sex Enhancement

Brand Name : Avanafil
Model Number : Avanafil
Certification : GMP/ISO9001
Place of Origin : China
MOQ : 1g
Price : Negotiation
Payment Terms : L/C, T/T, Western Union, MoneyGram
Supply Ability : 1000kg/month
Delivery Time : Within 3-7 work days after payment confirmed.
Packaging Details : Customized.
Name : Avanafil
CAS : 330784-47-9
MF : C23H26ClN7O3
MW : 483.95
Melting point : 150-152°C
density : 1.372
Chemical Properties : White Solid
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Male Enhancement Steroids Avanafil CAS 171596-29-5 for Sex Enhancement

Quick Detail:

Product Name: Avanafil
CAS: 330784-47-9
MF: C23H26ClN7O3
MW: 483.95
Purity: 99%min
Appearance: White crystalline powder
Standard: USP/BP/EP/Enterprise standard
Categories: Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's
Usage: A phosphodiesterase; Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM; Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor

Avanafil Description:

Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil is known by the trademark names and and was developed by Vivus Inc. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes. About two-thirds of the participants were able to engage in sexual activity within 15 minutes.


Avanafil is a strong, competitive inhibitor of PDE5. It is also 100-times more potent for PDE5 than PDE6. The IC50 of avanafil is 5.2 nM. Compared to other PDE5 inhibitor like sildenafil and vardenafil, it is 16- and 21-fold more selective for PDE5 respectively. Avanafil does not bind to PDE6 and PDE11 to a considerable degree. The impact of this finding is that avanafil is less likely to cause side effects such as visual disturbances and myalgia. These are side effects that patients on sildenafil or tadalafil are more likely to experience. Furthermore, single oral doses of avanafil (200 mg) administered to healthy male volunteers resulted in mean changes from baseline in systolic/diastolic blood pressure of -5.3/-3.7 mmHg at 1 hour after dosing. Avanafil does not causes changes in QTc interval or ventricular repolarization.

Avanafil Specifications:

Description: White or Almost White Crystalline Powderwhite powder
Identification: A.B.Positive
Assay: 97.0~103.0%99.3%
Specific Rotation: +101°~+105°+102.6°
Loss On Drying: 1.0%max0.27%
Melting Point: 153~157°C153.0~155.0°C
Organic Volatile Impurities: meets the requirement.Conforms
Related Substances: meets the requirement.Conforms
Residual Solvents: meets the requirement.Conforms
Particle Size: 100% ≤ 20 micronsConforms
ConclusionThe specification conform with USP30 standard

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