112809-51-5 Letrozole Femara Anti Estrogen for Cancer Treatment And
Letrozole / Femara Description
Letrozole (trade name Femara) is an oral aromatase inhibitor (AI)
used in the treatment of hormonally responsive breast cancer after
surgery. The FDA approved its use in post menopausal women who show
hormone receptor positive types of breast cancer. It was banned in
India in 2011 due to potential risk to infants when used in women
who are pregnant; however, a Canadian study done by the American
Society of Reproductive Medicine showed no evidence of birth
defects. As a result, it remains legal in the rest of the world.
Letrozole / Femara Use
Letrozole (letro) has many uses which have recently been
discovered. Aside from its female breast cancer use (typical of all
AI's), letro has off-label uses in medicine. Since 2001, the main
off label usage has been as a fertility drug because of its ability
to stimulate ovaries. Another use, because of its strong anti-estrogen properties, is to
use in a stack with misoprostal for early pregnancy termination. It
also has off label use as a treatment for gynecomastia, and it's
used in a stack with growth hormone to help adolescent boys grow
taller. It even promotes spermatogenesis in male patients (boosting
sperm count). Femara is fairly inexpensive, which makes it a unique
and versatile drug.
Since letrozole is such a powerful AI, it can be a great weapon to
combat emergency situations, where estrogen related sides get out
of control. When an anabolic steroid user uses compound such as
testosterone, dianabol, deca durabolin,equipoise etc; they will aromatize in the body and convert to
estrogen. This can result in multiple estrogen side effects such as
water retention, which has a domino effect and can effect your
libido, sleep, blood pressure, and energy. Another dangerous
estrogen side effect is gynecomastia (bitch tits), which, if left
untreated, can require expensive and invasive surgery. For this
reason, it is crucial to run an aromatase inhibitor if you use
aromatizing steroids during your cycle.
How does Letrozele / Femara work?
Similar to all aromatase inhibitors (AIs), letrozole, by binding to
the aromatase enzyme, prevents estrogen from being released. It is
known as a type II aromatase inhibitor.
It is the most powerful AI available; in fact, studies have shown
it to drops estrogen levels in women by up to 98%. In men, clinical
studies have shown a drastic reduction in estrogen levels very
quickly of up to 65%. The main reason may be because it has the
ability to crush estrogen through competitive/reversible binding to
the heme of the relevant cytochrome P450 unit (protein enzyme).
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Letrozole vs Aromasin and Arimidex
Letrozole is not a suicide aromatase inhibitor, meaning it will not
permanently disable the aromatase enzyme, so it is not the same as
aromasin. The other difference is letro is far more powerful at crushing
estrogen levels than either aromasin or arimidex. I would use it in emergency situations over the others, but I
wouldn't abuse it.
Letrozole Dosage and Half-Life
The half life is approximately 2-4 days. Dosages vary quite a bit,
0.25mg up to 1mg every day or every other day is a good starting
dose. It's best to be conservative with the dosage because if you
overdose the sides can be harsh.
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